Domilise’s serves some of the best classic roast beef, fried oysters and fried shrimp po-boys in NOLA. Founded in 1924, this family owned no frills uptown po-boy shop and bar is a respected institution and a daily lunch spot with a large local clientele. Enter this timeworn building and immediately get in line to order from the open po-boy kitchen counter. Your po-boy appears within a few minutes – a product of a whirlwind assembly process run by a 3-person team of pros. Heck, I’d pay just to watch them make me a po-boy. Order beverages from the bar.
I go for the fried oyster po-boy, dressed with hot sauce and washed down with a local beer – preferably Abita Amber.
Don’t expect a high level of service. Busy = gruff, no-nonsense, no time for tourist’s questions or behavior. This is a no frills place that prides itself on freshly fried seafood. They trade off manners for fresh – and I am all for that. On the other hand, if you get there a bit early, you’ll meet some of the nicest folks in NOLA and get a po-boy so fresh from the fryer that you’ll see steam rising off the bread.
Located at 5240 Annunciation Street in Uptown upriver from the garden district – one block off of Tchopitoulas St. 10 AM to 7 PM, closed Thursdays and Sundays, no website.
504.899.9126 | 
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Address: 5240 Annunciation St, New Orleans, LA 70115